Getting My ceesdekker To Work

Getting My ceesdekker To Work

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Using solitary-molecule optical and AFM imaging and pressure-spectroscopy strategies, we seek out to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our analysis interests contain:

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Sculpting nano-electrodes using a transmission electron beam for electrical and geometrical characterization of nanoparticles.

This yielded a breakthrough. In only a few months, we ended up capable of evaluate transport as a result of someone single-walled carbon nanotube. Based upon minimal-temperature experiments by a superb PhD college student in my group, Sander Tans (now a valued colleague and professor at Delft University of Technology using an Lively analysis lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes had been authentic quantum wires with very very long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.

Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes

‘In the beginning we checked out Organic methods that has a physical perspective and acted on the basis on the applications we knew. It took a several years right before we started Doing work extra on the big biological troubles. I then began to connect with it nanobiology, a term that did not exist at time.

Illustration (one) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is demonstrated in gray, the rim from the pore is highlighted in purple, as well as a 3D rendering of your motion of your DNA rod is shown.

‘Of course, I realize men and women ended up astonished at the time. At the conclusion of the nineties, Once i was in my forties, I used to be Professor of Molecular Electronics and I have to admit that it experienced become a little bit bored, I didn’t discover Considerably anymore. The sector went a lot more into the appliance aspect, how you might combine nanotubes into electronic circuits.

Resolving the move dimension in condensin-driven DNA loop extrusion identifies ATP binding given that the stage-producing method

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial mobile division

‘That worries the synthetic cell, as part of the Dutch BaSyC initiative. Craig Venter seemed top-down in People times and recognized about 5 hundred genes which can be minimally demanded for the functioning cell. We wish to search base-up: how do we shift from a number of molecules to an entire biological process?

Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes

Solid-state nanopores have verified being a astonishingly functional probe for single-molecule Evaluation of DNA. I'll explain a few of our modern conclusions – precisely DNA knots – in addition to our efforts to increase the abilities https://www.ceesdekker.net of stable-point out nanopores even further, within the route of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.